Klemens Rottner Selected Research

Cortactin

4/2022	The Actin-Binding Protein Cortactin Promotes Sepsis Severity by Supporting Excessive Neutrophil Infiltration into the Lung.
8/2021	Helicobacter pylori CagA Induces Cortactin Y-470 Phosphorylation-Dependent Gastric Epithelial Cell Scattering via Abl, Vav2 and Rac1 Activation.
6/2021	Cortactin Is Required for Efficient FAK, Src and Abl Tyrosine Kinase Activation and Phosphorylation of Helicobacter pylori CagA.
12/2020	Actin-Binding Protein Cortactin Promotes Pathogenesis of Experimental Autoimmune Encephalomyelitis by Supporting Leukocyte Infiltration into the Central Nervous System.
1/2019	Role of Src and Cortactin in Pemphigus Skin Blistering.
1/2019	High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse.
1/2014	Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src.
7/2009	Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases.

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Klemens Rottner Research Topics

Disease

10	Cicatrix (Scar) 01/2020 - 10/2002
6	Infections 04/2022 - 06/2003
6	Neoplasms (Cancer) 01/2022 - 06/2008
4	Melanoma (Melanoma, Malignant) 01/2019 - 01/2009
2	Blister (Bulla) 10/2019 - 01/2019
1	Lung Injury 04/2022
1	Sepsis (Septicemia) 04/2022
1	Adenocarcinoma 08/2021
1	Stomach Neoplasms (Stomach Cancer) 06/2021
1	Demyelinating Diseases (Demyelinating Disease) 12/2020
1	Multiple Sclerosis 12/2020
1	Inflammation (Inflammations) 12/2020
1	Neuroinflammatory Diseases 12/2020
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 12/2020
1	Pancreatic Neoplasms (Pancreatic Cancer) 11/2019
1	Neoplasm Metastasis (Metastasis) 11/2019
1	Pemphigus (Pemphigus Vulgaris) 01/2019
1	Leukemia 01/2019
1	Autoimmune Diseases (Autoimmune Disease) 01/2019
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2019
1	Fibrosis (Cirrhosis) 01/2018
1	Ovarian Neoplasms (Ovarian Cancer) 04/2016
1	Bone Resorption 01/2014
1	Tetraploidy 08/2013
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2013
1	Wiskott-Aldrich Syndrome 11/2010
1	Glioblastoma (Glioblastoma Multiforme) 05/2006
1	autosomal recessive 1 Spinocerebellar ataxia 06/2003

Drug/Important Bio-Agent (IBA)

8	CortactinIBA 04/2022 - 07/2009
8	Actin-Related Protein 2-3 Complex (Arp2 3 Complex)IBA 01/2020 - 10/2002
6	Proteins (Proteins, Gene)FDA Link 08/2021 - 10/2002
4	Microfilament Proteins (Actin Binding Proteins)IBA 04/2022 - 01/2019
3	Wiskott-Aldrich Syndrome Protein FamilyIBA 01/2020 - 10/2002
3	ForminsIBA 01/2019 - 01/2017
3	Wiskott-Aldrich Syndrome ProteinIBA 11/2013 - 10/2002
2	Tyrosine (L-Tyrosine)FDA Link 08/2021 - 06/2021
2	Phosphotransferases (Kinase)IBA 06/2021 - 01/2020
2	Protein Isoforms (Isoforms)IBA 01/2020 - 10/2019
2	Actins (F Actin)IBA 11/2018 - 01/2009
2	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 01/2018 - 02/2004
2	Cyclic AMP Receptors (Cyclic AMP Receptor)IBA 09/2013 - 06/2006
1	Fenofibrate (CiL)FDA LinkGeneric 01/2022
1	Cell Adhesion MoleculesIBA 01/2022
1	CarcinogensIBA 08/2021
1	src-Family KinasesIBA 08/2021
1	Biomarkers (Surrogate Marker)IBA 06/2021
1	CytokinesIBA 12/2020
1	Proline (L-Proline)FDA Link 01/2020
1	lysophosphatidic acidIBA 11/2019
1	DesmogleinsIBA 01/2019
1	AutoantibodiesIBA 01/2019
1	Peptides (Polypeptides)IBA 12/2017
1	myosin VIIBA 04/2016
1	Coat Protein Complex I (COPI)IBA 01/2016
1	Actin-Related Protein 2IBA 09/2013
1	PhosphatidylserinesIBA 08/2013
1	metavinculinIBA 01/2013
1	Octoxynol (Triton X 100)IBA 01/2009
1	Matrix Metalloproteinase 14 (MT1-MMP)IBA 06/2008
1	Peptide Hydrolases (Proteases)FDA Link 06/2008
1	SNARE Proteins (SNAREs)IBA 06/2008
1	nucleic acid probe 1IBA 06/2006
1	rho-Associated KinasesIBA 05/2006
1	Multiprotein ComplexesIBA 02/2004

Therapy/Procedure

1	Punctures 04/2022
1	Ligation 04/2022
1	Traction 05/2006